Pesquisa | SciELO

Rutin is found in several plant sources and has therapeutic effects with excellent healing potential. Its use is restricted due to its low aqueous solubility, requiring a carrier matrix that allows an adequate delivery system. Biopolymer matrices can release the active ingredient in a controlled manner, keeping it within the therapeutic range and minimizing side effects. This study used babassu mesocarp starch films prepared by different routes as Arrabidaea brachypoda DC Bureau (AB) leaf extract carrier matrices to produce a controlled release system. The films were produced by the casting method, and the AB extract was incorporated in the proportion of 0.5% m/m of dry starch. The presence of the extract in the matrix was identified with Fourier transform infrared spectroscopy (FTIR) and X-ray diffractometry (XRD) data and functional analyses. The in vitro release of the AB extract was carried out in phosphate-buffered saline, pH 7.4, and adapted to the Korsmeyer-Peppas model, with coefficients of determination (R2) ≥ 0.9018. The release exponents (n) revealed that the release mechanism is diffusion controlled. Different kinetic constant values (k) indicated that the treatments employed allowed slower and more controlled release profiles, according to the route chosen for matrix preparation. Thus, the materials produced emerge as a new approach to releasing vegetable extracts.

ABSTRACT Celtis iguanaea (Jacq.) Sarg., Cannabaceae, is popularly used in the treatment of diabetes mellitus. However, chemical and pharmacological investigations are lacking. In this study, we investigated the effects of the hydroalcoholic extract from C. iguanaea on markers of cardiovascular diseases and the glucose metabolism in cholesterol-fed rats. Therefore, hypercholesterolemic rats (1% cholesterol) were orally treated with C. iguanaea extract (C-150, CI-300, or CI-600 mg/kg) or simvastatin (4 mg/kg) (n = 6) once a day (30 days) with a hypercholesterolemic diet. A control group (C) was given saline. C. iguanaea extract showed significant decreases in serum levels of total cholesterol, LDL-cholesterol, HMG-CoA-reductase, interleukin-1 and 6, TNF-α and IFN-γ when compared to group C (p < 0.001). Hypoglycemic effects were observed along with a decrease of the activity of sucrase (CI-600), maltase (CI-150, CI-300), and an increase in muscle glycogen levels (CI-300). Antioxidant effects were observed in plasma by the decrease of TBARS and increase of nonprotein thiols levels (CI-600). The histopathological analysis showed a significant decrease in the liver fat area for C. iguanaea extract compared to group C (p < 0.001). Our results suggest that the biological effects of C. iguanaea extract could be related to the flavonoids that possibly exert antioxidant, enzymatic inhibitory, and insulin-mimetic effects.

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ta	título abreviado da revista (ex. Cad. Saúde Pública)
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la	código do idioma da publicação (ex. pt - Português, es - Espanhol)
type	tipo do documento
pid	identificador da publicação
publication_year	ano de publicação do artigo
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aff_institution	instituição de afiliação do autor
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